| Pos. | No. | Driver | Entrant | Car | Time | Grid |
|---|---|---|---|---|---|---|
| 1 | 8 | Emmanuel de Graffenried | Scuderia Enrico Platé | Maserati A6GCM | 2:57:31 | 4 |
| 2 | 4 | Louis Chiron | Louis Chiron | O.S.C.A. Tipo 20 | +3 laps | 7 |
| 3 | 16 | Rodney Nuckey | Rodney Nuckey | Cooper T23-Bristol | +6 laps | 10 |
| 4 | 14 | Eric Brandon | Cooper Car Company | Cooper T20-Bristol | +6 laps | 9 |
| 5 | 6 | Peter Whitehead | Peter Whitehead | Cooper T24-Alta | +6 laps | 8 |
| NC | 30 | Charles de Tornaco | Ecurie Francorchamps | Ferrari 500 | 14 | |
| NC | 18 | Giovanni de Riu | Scuderia Enrico Platé | Maserati 4CLT-48 | 12 | |
| NC | 22 | Mario Raffaeli | Scuderia Marzotto | Ferrari 166 | 13 | |
| Ret | 2 | Giuseppe Farina | Scuderia Ferrari | Ferrari 500 | 61 laps, mechanical | 2 |
| Ret | 26 | Mike Hawthorn Alberto Ascari |
Scuderia Ferrari | Ferrari 500 | 57 laps, valves | 5 |
| Ret | 24 | Alberto Ascari | Scuderia Ferrari | Ferrari 500 | 37 laps, valves | 1 |
| Ret | 28 | Sergio Mantovani | Officine Alfieri Maserati | Maserati A6GCM | 36 laps, accident | 11 |
| Ret | 10 | Tom Cole | Atlantic Stable | Cooper T23-Bristol | 36 laps, accident | 6 |
| Ret | 12 | Luigi Villoresi | Scuderia Ferrari | Ferrari 500 | 3 laps, valves | 3 |
| DNA | 20 | Officine Alfieri Maserati | Maserati A6GCM | entry withdrawn | - |
Date: 22 March 1953
Official Name: III Gran Premio di Siracusa
Circuit: Syracuse Circuit
Location: Syracuse, Sicily
Circuit Length: 5.400 km
Number of Laps: 80
Race Distance: 431.979 km
Pole Position: Alberto Ascari, Ferrari
Fastest Lap: Alberto Ascari, Ferrari, 2:05.0