The 44th International 500-Mile Sweepstakes was held at the Indianapolis Motor Speedway in Speedway, Indiana on Monday, May 30, 1960. The event was race 2 of 12 of the 1960 USAC National Championship Trail and was also race 3 of 10 in the 1960 Formula One season. It would be the final time World Championship points would be awarded at the Indy 500.

Often regarded as the greatest two-man duel in Indianapolis 500 history, the 1960 race saw a then-record 29 lead changes. Jim Rathmann and Rodger Ward battled out nearly the entire second half. Rathmann took the lead for good on lap 197 after Ward was forced to slow down with a worn out tire. Rathmann's margin of victory of 12.75 seconds was the second-closest finish in Indy history at the time.