The 1980 Italian Grand Prix was a Formula One motor race held on 14 September 1980 at the Autodromo Dino Ferrari in Imola. It was the twelfth race of the 1980 Formula One season.

This was the first Formula One World Championship race to be held at Imola. It was the only Italian Grand Prix since 1948 not to be held at Monza, which was undergoing refurbishment at the time.

The race was won by Brazilian driver Nelson Piquet, driving a Brabham-Ford. Piquet won by nearly half a minute from Australian driver Alan Jones, driving a Williams-Ford, with Jones' Argentine team-mate Carlos Reutemann third. The win was Piquet's third of the season and second in succession, and it gave him the lead of the Drivers' Championship by one point from Jones. Jones' and Reutemann's podium finishes enabled the Williams team to secure their first Constructors' Championship with two races remaining.