The 1980 Monaco Grand Prix was a Formula One motor race held at Monaco on 18 May 1980. It was the sixth round of the 1980 Formula One season.

The race was won by Carlos Reutemann driving a Williams FW07B after polesitter Didier Pironi crashed at the Casino corner on lap 55. The win was the Argentine Reutemann's tenth Formula One victory and his first since the 1978 United States Grand Prix. He also became the fifth winner in six races of the 1980 season. Reutemann won by 1 minute and 13 seconds over French driver Jacques Laffite driving Ligier JS11/15. Third was Brazilian driver Nelson Piquet driving a Brabham BT49.

The race however is remembered for a memorable and spectacular crash at the start of the race when Derek Daly collided with Bruno Giacomelli's Alfa Romeo 179, which sent Daly's Tyrrell 010 flying over Giacomelli and landing between teammate Jean-Pierre Jarier and Alain Prost's McLaren M29. All four drivers were out on the spot, but none suffered any serious injury. Jan Lammers also collected damage in his ATS D4 but was able to continue.