The 1980 South African Grand Prix was a Formula One motor race held on 1 March 1980 at Kyalami in Gauteng. It was the third round of the 1980 Formula One season.

The race was won by French driver René Arnoux driving a Renault RE20. Arnoux won by 34 seconds over fellow French driver Jacques Laffite driving a Ligier JS11/15. Laffite's Ligier teammate Didier Pironi was third, completing an all-French podium. This was the first race since the 1968 United States Grand Prix to have three drivers from the same country on the podium; all three were also driving French-built cars.

The race was additionally notable because of two accidents during qualifying: French driver Alain Prost broke his wrist when he crashed his McLaren M29 at the Esses after a suspension failure, while Swiss driver Marc Surer badly injured his legs when he crashed the new ATS D4 at Crowthorne Corner at the end of the straight. Neither started the race, with Prost also missing the following race and Surer the next three races.