The 1990 Mexican Grand Prix was a Formula One motor race held at Autodromo Hermanos Rodriguez on 24 June 1990. It was the sixth race of the 1990 Formula One World Championship.

The race was won by reigning world champion, French driver Alain Prost driving a Ferrari 641. It was Prost's second win of the year. Prost won the race by 26 seconds over his British teammate Nigel Mansell. Third was Austrian driver Gerhard Berger. Ayrton Senna stopped with a puncture late in the race, allowing both Prost and Berger to close to eight points behind him in the Driver's Championship.