The 1993 South African Grand Prix was a Formula One motor race held at Kyalami on 14 March 1993. It was the first race of the 1993 Formula One World Championship.

The race was won by Frenchman Alain Prost, driving a Williams-Renault. Prost, returning to Formula One after taking the 1992 season off, took pole position and led the last 49 laps, winning by over a minute from Brazilian Ayrton Senna in a McLaren-Ford. Briton Mark Blundell finished third in a Ligier-Renault.

The racemarked the debut of the Swiss Sauber team, who scored their first points courtesy of Finn JJ Lehto's fifth-place finish.

This was the first time since 1974 that the first race of a season did not feature the defending Drivers' Champion in the field. Defending 1992 champion Nigel Mansell had moved to race in CART for the season. Defending Constructors' Champion Williams could not use No. 1 on either of its cars. Therefore, this was the first race since the 1973 United States Grand Prix that number 0 was used.