The 2000 United States Grand Prix was a Formula One motor race held on 24 September 2000 at Indianapolis Motor Speedway in Speedway, Indiana. It was the 15th round of the 2000 Formula One World Championship. Ferrari driver Michael Schumacher won the race from pole position. His teammate Rubens Barrichello finished second with Jordan's Heinz-Harald Frentzen third.

Before the race, McLaren's Mika Häkkinen led Michael Schumacher by two championship points in the World Drivers' Championship while McLaren led Ferrari by four championship points in the World Constructors' Championship. Michael Schumacher took pole position by setting the best lap in the qualifying session. McLaren's David Coulthard started second. However, Coulthard had to serve a ten-second stop-go penalty on lap eight because he jumped the start. Häkkinen started third, but retired on lap 26 with a blown engine due to a pneumatic valve system failure. Michael Schumacher thus had an uncontested lead after passing Coulthard on lap seven, and despite losing control of his Ferrari in the final five circuits of the race, he went on to win his seventh race of the season and 42nd overall. Barrichello finished second, 12.1 seconds behind, and Frentzen finished third, holding off British American Racing's Jacques Villeneuve in the final laps.

Michael Schumacher retook the lead in the World Drivers' Championship by eight championship points over Häkkinen following the race. Ferrari retook the World Constructors' Championship lead from McLaren, establishing a ten-point lead with two races left in the season.