The 2001 Spanish Grand Prix was a Formula One motor race held on 29 April 2001, at the Circuit de Catalunya in Montmeló, Catalonia. It was the fifth round of the 2001 Formula One World Championship. Ferrari's Michael Schumacher won the race from pole position. Williams's Juan Pablo Montoya finished second for his first Formula One podium finish and British American Racing's Jacques Villeneuve finished third.

Michael Schumacher set the fastest lap in the qualifying session, securing pole position. He held the lead until the two pit stop cycles, when Coulthard's teammate Mika Häkkinen took the lead each time round due to his longer stints than Schumacher's. Häkkinen took the lead after the second round of stops because McLaren told him to push to get ahead of Schumacher, whose rear tyres began to vibrate. Häkkinen led the race and appeared set to win until his clutch failed on the final lap due to a hydraulic leak. Michael Schumacher took the lead and won by 40 seconds over Montoya.

Electronic driver aids including traction control, fully automatic gearboxes, and launch control became legal for the first time since the 1993 season at the Spanish Grand Prix.