The 2001 United States Grand Prix was a Formula One motor race held on September 30, 2001, at the Indianapolis Motor Speedway in Speedway, Indiana. It was the 16th and penultimate round of the 2001 Formula One World Championship. It was the first international sporting event to take place in the United States since the September 11 attacks, which occurred 19 days before the Grand Prix. McLaren's Mika Häkkinen won the race after starting fourth. Ferrari's Michael Schumacher finished second, while Häkkinen's teammate David Coulthard was third.

Michael Schumacher took pole position after setting the fastest qualifying lap, with Häkkinen second. Häkkinen's best time, however, was deleted by the stewards after he was penalized for a pit lane infraction during the warm-up session and dropped to fourth on the basis of his second-best qualifying lap. Michael Schumacher led the opening four laps before relinquishing the lead to teammate Rubens Barrichello. Before his first of two pit stops on lap 27, Barrichello had built up a significant lead over his teammate. Häkkinen used his engine's low fuel usage to take the lead and keep it until his lone pit stop on the 46th lap, when he dropped to second. Barrichello retook the lead for four laps, and Häkkinen led the rest of the race to claim his second victory of the season and the 20th (and final) of his career after Barrichello was forced to retire two laps from the finish due to an engine failure.

The final result meant that Michael Schumacher broke the all-time record for most points scored in a season, which he shared with Nigel Mansell.