The 2010 FIA Formula One World Championship was the 64th season of FIA Formula One motor racing. The season's first race was held on 14 March in Bahrain and the season concluded on 14 November in the United Arab Emirates after 19 motor races held in 18 countries on five continents. Red Bull Racing won its maiden Constructors' Championship with a 1–2 finish in Brazil, while Red Bull Racing's Sebastian Vettel won the Drivers' Championship after winning the final race of the season in Abu Dhabi. In doing so, Vettel became the youngest World Drivers' Champion in the 61-year history of the championship. Vettel's victory in the championship came after a dramatic season finale at Abu Dhabi where three other drivers could also have won the championship – Vettel's Red Bull Racing teammate Mark Webber, Ferrari's Fernando Alonso and McLaren's Lewis Hamilton.

This was Bridgestone's final season as the sole tyre supplier in Formula One as the company announced that it would not renew its contract at the end of the season. After several months of deliberation, Pirelli was chosen as the tyre supplier for the 2011 season at the FIA World Motor Sport Council meeting in Geneva, in June 2010.

The points system was changed, with 25 points being awarded for first place, 18 for second, 15 for third, then 12, 10, 8, 6, 4, 2, and 1 for fourth to tenth. The technical and sporting regulations applicable for the season were the subject of much debate.

Before the start of the season, 2009 Drivers' Champion Jenson Button joined McLaren, while the 2009 Constructors' Champion, Brawn GP, was bought by German motor vehicle manufacturer Mercedes-Benz and was renamed as Mercedes GP. The 2010 season saw the return of the most successful driver in Formula One history at that point, with seven-time World Champion Michael Schumacher coming out of retirement after a three-year absence since 2006.