The 2010 Abu Dhabi Grand Prix was a Formula One motor race held on 14 November 2010 at the Yas Marina Circuit on Yas Island. It was the nineteenth and final round of the 2010 Formula One season. The 55-lap race was won by Red Bull driver Sebastian Vettel after starting from pole position. Lewis Hamilton finished second in a McLaren, and teammate Jenson Button completed the podium, in third place.

A second race win in succession – as well as a second consecutive Abu Dhabi Grand Prix win – for Vettel, coupled with other championship contenders Hamilton, Fernando Alonso and Mark Webber finishing second, seventh and eighth respectively, allowed him to become the youngest World Drivers' Champion, at the age of 23 years, 134 days.

Due to injuries sustained in a rally crash prior to the 2011 Formula One season, this was the last Formula One race for Robert Kubica until the 2019 Australian Grand Prix. This was also the last Grand Prix for Lucas di Grassi and Christian Klien. This event also notably marked the last race for Bridgestone as a tyre supplier in Formula One, since their full time debut in 1997. Pirelli became the sole tyre supplier for all teams in 2011.