The 2010 Brazilian Grand Prix was a Formula One motor race held at the Autódromo José Carlos Pace in the city of São Paulo on 7 November 2010. It was the 18th round of the 2010 Formula One World Championship. Red Bull driver Sebastian Vettel won the race starting from second. His teammate Mark Webber finished second and Ferrari's Fernando Alonso third.

Nico Hülkenberg for the Williams team took the first pole position of his career by recording the fastest lap time in the qualifying session. Vettel and Webber overtook Hülkenberg for the first two positions at the start of the race. Vettel was able to maintain the lead until his first pit stop to switch tyres and Webber led for two laps until he made his own pit stop. Vettel thereafter was able to maintain first position through negotiation of slower traffic for the rest of the race to take his fourth victory of the season and the ninth of his career. Webber was 4.2 seconds behind in second as Alonso drew closer to him in the final ten laps, albeit not close enough to pass and finished third.

Entering the event, Red Bull led McLaren by 27 points in the World Constructors' Championship. With their drivers finishing first and second, Red Bull won its first World Constructors' Championship.