The 2012 Brazilian Grand Prix was a Formula One motor race that took place at the Autódromo José Carlos Pace in São Paulo, on 25 November 2012. The race was the twentieth and final round of the 2012 Formula One World Championship.

The race was won by Jenson Button driving for McLaren, scoring the 15th and last victory of his Formula One career, as well as McLaren's last Grand Prix victory until Daniel Ricciardo's victory at the 2021 Italian Grand Prix and the last win for a British driver for McLaren until Lando Norris won the 2024 Miami Grand Prix.

It was at this race that Sebastian Vettel won the 2012 World Drivers' Championship, his third title in a row. Fernando Alonso finished second in both the race and the championship and had the provisional championship lead at a late stage of the race, before Vettel moved up the order to have a three-point cushion. The race also marked the 306th and final one for Michael Schumacher, after he announced his retirement for the second time. He also scored his final Formula One points by finishing seventh just behind eventual champion Vettel.