The 2021 São Paulo Grand Prix was a Formula One motor race, held on 14 November 2021 at the Interlagos Circuit in São Paulo. The race was the 19th round of the 2021 Formula One World Championship.

After being disqualified from Friday qualifying due to an inconformity with his drag reduction system, Lewis Hamilton started twentieth for the sprint race, recovering to fifth. After taking a further five-place grid penalty for the main race for exceeding the quota of internal combustion engines allocated to him, Hamilton caught up to, and ultimately passed, a leading Max Verstappen. Sprint polesitter Valtteri Bottas finished in third, which alongside Hamilton's victory, further extended Mercedes's advantage over Red Bull Racing in the fight for the Constructors' Championship; Verstappen would remain ahead of Hamilton in the Drivers' Championship standings.