The 2022 São Paulo Grand Prix was a Formula One motor race that was held on 13 November 2022 at the Interlagos Circuit in São Paulo, Brazil. It was the twenty-first and penultimate round of the 2022 Formula One World Championship and the third and final Grand Prix weekend in the season to utilise the sprint format.

Mercedes driver George Russell took his maiden Grand Prix win with his teammate Lewis Hamilton in second and with Ferrari driver Carlos Sainz completing the podium in third. This race marked the first time since the 2010 Canadian Grand Prix that British drivers finished first and second in a Grand Prix.